Institute of organic chemistry

The Department was founded by Academician A.V.Kirsanov on the basis of Pesticide Laboratory created in 1951. Since 1956 till 1978 the Department was headed by Prof. V.I.Shevchenko, since 1978 till 2009 Prof. O.M.Pinchuk guided the Department. Dr. O.M.Kostiuk was appointed the head of the Department in 2009. The staff is as follows: 2 Doctors of science, 15 Candidates of science, 7 engineers, 1 technician. The Department includes a Laboratory of Chemical Processes Under Pressure guided by Ph.D. O.O.Yurchenko.
The priority direction of research is the search for new reactions in organo-phosphorus compounds chemistry, synthesis and study of new types of organo-element heterocycles. The aim of the research is development of basic methods for phosphorus- and fluorine-containing analogs of natural bio-active compounds, design of new type phosphorus-containing ligands for metal-complex catalysis.
During the last years the Department has conducted fundamental research on creation of the bond phosphorus-carbon, original methods of electrophilic phosphorylation of electron-enriched unsaturated aromatic and heterocyclic compounds by tri-valence phosphorus halogenides elaboration, a general approach to the synthesis of condensed phosphorus-containing heterocycles, hardly available 5-phosphinines and 5-azaphosphinines, chiral amino-trifluoromethyl ketones and heterocumulens on their base has been elaborated.
The first representatives of dialkylaminophosphetanes, trichloroylydes and other phosphorus-containing heterocycles have been obtained. A series of new halogen-phoshpines with perchloroalkyl, adamantyl, hetero-aromatic substituents and a lot of functionally substituted organo-phosphorus compounds important for synthetic chemistry have been created.
Phosphine ligands are of special interest. Introduction of heteryl fragments to the known and new phosphine ligands allows to change their electronic properties in a wide range and to obtain highly effective catalysts with new properties. The work on the synthesis and study of new catalysts on the base of ferocenylpolyphosphines is conducted jointly with the laboratories of Burgundy and Lion Universities (France).

1. Konovets, A. I.; Kostyuk, A. N.; Pinchuk, A. M. Tolmachev, A. A.; Fischer, A.; Jones,P.G.;Schmutzler,R. Dichloro(diisopropylamino)phosphonio[5(4H)oxopyrazol-4-ylide-5-one]: Synthesis and properties. // Heteroatom Chem. – 2003. – Vol. 14. – P. 452-458.
2. Marchenko, А. P.; Koidan, G. N.; Kostyuk, A. N.; Tolmachev, A. A.; Kapustin, E. G.; Pinchuk. A. M. A Representative of P,P,P-Trihalogenylides: Synthesis and Structure. // J. Org. Chem. – 2006. – Vol. 71. – P. 8633-8636.
4. Volochnyuk, D. M.; Kostyuk, A. N.; Sibgatulin,D. A.; Petrenko,A. E. Unexpected Addition of Methyl 3,3,3-Trifluoropyruvateto ‘Push-Pull’ Enamines Having a MethylGroup at ?-Position // Synthesis – 2004. – Vol. 15. – P. 2545-2549.
5. Sibgatulin,D. A.; Volochnyuk, D. M.; Kostyuk, A. N. Reaction of unsymmetrical trifluoromethyl-containing 1,3-dicarbonyl compounds with ‘push–pull’ enamines // Тetrahedron Lett. – 2007. – Vol. 48. – P. 2775-2779.
6. Svyaschenko, Y. V.; Kostyuk, A. N.; Barnych, B. B.; Volochnyuk, D. M. A convenient approach to ?5-phosphinines via interaction of phosphorylated 3-pyrrolidinocrotonitrile with 2-bromoacetophenones // Tetrahedron. – 2007. – Vol. 63. – P. 5656-5664.
6. Sukach, V. A.; Golovach, N. M.; Pirozhenko, V. V.; Rusanov, E. B.; Vovk, M. V. Convenient enantioselective synthesis of ?-trifluoromethyl-?-aminoketones by organocatalytic asymmetric Mannich reaction of aryl trifluoromethyl ketimines with acetone. // Tetrahedron: Asymmetry. – 2008. – Vol. 19. – P.761-764

	Institute of organic chemistry National academy of sciences of Ukraine

ORGANOPHOSPHORUS COMPOUNDS CHEMISTRY DEPARTMENT